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Case No. 760
2026-08-01~2026-08-31
출제자 : 전영훈
Hit : 265
| Period | 2026-08-01~2026-08-31 |
|---|---|
| Diagnosis | Supratentorial ependymoma, ZFTA fusion-positive |
| Gender |
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| Age | 24 |
| Clinical information | 24-year-old woman undergoing follow-up for an incidentally discovered brain lesion. What is the diagnosis? |
| Discussion | Epidemiology Children and adults, male predominant Molecular markers ZETA fusion (with RELA or other genes) CDKN2A/B loss Imaging features Enhancing mass with cysts, hemorrhage Peritumoral edema Recurrence along the dural flap Imaging features that raise suspicion for supratentorial ependymoma rather than high-grade glioma Superficially located, well-circumscribed supratentorial mass Dominant cystic component Eccentric enhancing solid tissue Calcification Reference Soni N, Ora M, Bathla G, Desai A, Gupta V, Agarwal A. Ependymal Tumors: Overview of the Recent World Health Organization Histopathologic and Genetic Updates with an Imaging Characteristic. AJNR Am J Neuroradiol. 2024 Nov 7;45(11):1624-1634. |
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