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Case No. 730
2025-09-01~2025-09-30
출제자 : 주비오
Hit : 443
| Period | 2025-09-01~2025-09-30 |
|---|---|
| Diagnosis | Myxoid glioneuronal tumor |
| Gender |
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| Age | 35 |
| Clinical information | F/35 Papilledema What's your diagnosis? |
| Discussion | Myxoid glioneuronal tumor (MGNT or MGT) is a benign glioneuronal neoplasm that was recently recognized as a distinct entity in the 2021 WHO classification. MGTs are classified as CNS WHO grade 1 tumors and generally follow an indolent clinical course with a favorable long-term prognosis. Histologically, MGTs are almost indistinguishable from dysembryoplastic neuroepithelial tumors. However, they are unique at the molecular level, as they represent the only CNS tumor entity known to harbor PDGFRA mutation as a solitary genetic driver. These tumors typically arise in the septum pellucidum, the periventricular white matter of the lateral ventricle, or the foramen of Monro. On MRI, they usually appear as T1 hypointense and T2 hyperintense lesions, without contrast enhancement or diffusion restriction. Ref: Neoplasia. 2023 Mar:37:100885. doi: 10.1016/j.neo.2023.100885 |
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