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종결 Case No. 622 2022-04-01~2022-04-30
출제자 : 임영희 Hit : 652
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Period 2022-04-01~2022-04-30
Diagnosis brain abscess
Clinical information 70/M
LOC, GTC seizure
진단은?
Discussion Definitions
Localized infection of brain parenchyma, typically bacterial; fungal or parasitic less common
4 pathologic stages: Early cerebritis, late cerebritis, early capsule, late capsule

# Image findings
1>Early cerebritis
CT: Ill-defined, hypodense subcortical lesion with mass effect; CT may be normal early
MR:Poor marginated T1 hypo-iso SI, T2 hyper SI, Patchy enhancement
2>Late cerebritis
CT: Central low-density area; peripheral edema, increased mass effect, Irregular rim enhancement
MRL T1 Hypointense center, iso-/mildly hyperintense rim, T2 Hyperintense center, hypointense rim; hyperintense edema, Intense, irregular rim enhancement.
3> Early capsule
CT: Low-density center with thin, distinct enhancing rim
MR: T1 Rim iso-/hyperintense to white matter (WM); center hyperintense to CSF
T2 Hypointense rim (due to collagen, hemorrhage, or paramagnetic free radicals)
Well-defined, thin-walled enhancing rim
4> Late capsule
CT: shrinks, capsule thickens,
MR: Cavity shrinks, capsule thickens
DWI: Increased signal intensity in cerebritis and abscess
ADC map: Markedly decreased signal (low ADC) centrally within abscess
MRS; Central necrotic area may show presence of amino acids (0.9 ppm), lactate (1.3 ppm), acetate (1.9 ppm), succinate (2.4 ppm)
PWI: Abscess capsule shows lower rCBV values than rims of enhancing tumors

Reference
Diagnostic Imaging: Brain, 3rd Edition
Anne G Osborn & Miral D Jhaveri & Karen L. Salzman & A. James Barkovich

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