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종결 Case No. 537 2019-12-01~2019-12-31

출제자 : 유인선 Hit : 307

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Period	2019-12-01~2019-12-31
Diagnosis	Gliosarcoma
Gender	M F
Age	55
Clinical information	M/55 2주 전부터 시작된 general weakness, dysphagia, gait disturbance 진단은?
Discussion	Gliosarcoma Introduction  Both gliomatous + sarcomatous components  Rare CNS neoplasm (1.8%~2.6%)  Peak: 5th-6th decade, slight male preponderance  Recent genetic studies suggest a monoclonal origin of gliosarcoma and an evolution of sarcomatous component due to acquisition of a mesenchymal phenotype in a highly malignant astrocytic tumor  Worse prognosis than GBM  Treatment - Adjuvant therapy (radiotherapy, chemotherapy) is recommended  Recurrence common Imaging findings of Gliosarcoma  In temporal (44%) and parietal (28%) lobes  Peripheral tumor location with dural involvement  Gliosarcoma with meningioma like appearance  Well circumscribed, homogenous enhancement  High sarcomatous component  High propensity to metastasize  Worse prognosis  Gliosarcoma with GBM like appearance  Heterogeneous, ill-defined lesion with patchy/ring enhancement
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