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종결 Case No. 526 2019-08-01~2019-08-31
출제자 : 강경미 Hit : 490
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Period 2019-08-01~2019-08-31
Diagnosis Heat stroke Related Brain Injury
Gender
  • M
  •  
  • F
Age 78
Clinical information M/78
Altered mentality(1HA)
진단은?
Discussion (Initial body temperature : 41.3C)

 Heat stroke: Medical emergency defined by a body temperature greater than 40°C causing altered mental status and deterioration of multiple organ system

 Image finding of CNS involvement
1) MRI
Diffusion restriction: Cerebellum, Thalami, Dentate nuclei, Bilateral SCP, Midbrain, cerebral cortices
T1WI/T2WI : HSI of paraventricular thalamus, external capsule, cerebellum
2) CT
Loss of Gray matter-White matter discrimination
Cerebellar atrophy
 Mechanism
Systemic cytokine increases BBB leakiness causing vasogenic edema
Small vessel ischemia d/t augumented hemostasis and microvascular disease
Direct toxic effect of heat on cerebellar purkinje cells
 Prognosis: poor (Mortaility rate : 10%-50%)
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  • 문성준 경북대학교병원

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