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Case No. 481
2018-05-01~2018-05-31
출제자 : 이아름
Hit : 328
| Period | 2018-05-01~2018-05-31 |
|---|---|
| Diagnosis | Diffuse midline glioma, H3K27M-mutant |
| Clinical information | 53/M C.C: mental change |
| Discussion | -New diagnostic entity in 2016 WHO classification -Characteristic features - Typical locations : midline(thalamus, pons, sp. cord) - Usually in children and young adults - Confirmed only by genotype : H3 K27M mutation + - Histology : Infiltrative astrocytic tumor cells - WHO grade IV -Image findings : may be variable Suggested imaging Dx., when diffuse infiltrating glioma in typical midline locations Reference: Brain Pathol. 2016 Sep;26(5):569-80 AJNR Am J Neuroradiol. 2017 Feb 9. doi: 10.3174/ajnr.A5076 |
| Correct answer |
Correct AnswerSemi-Correct Answer |