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Case No. 422
2016-10-01~2016-10-31
출제자 : 차지훈
Hit : 387
| Period | 2016-10-01~2016-10-31 |
|---|---|
| Diagnosis | Huntington disease |
| Clinical information | F/62 C.C> gait disturbance |
| Discussion | Imaging findings - Atrophy of the head of the caudate nucleus - Atrophy of putamen, iron deposition - Diffuse brain atrophy Review - Autosomal dominant neurodegenerative disease CAG trinucleotide repeat disease (chromosome 4p16.3) Huntington protein accumulate in nucleus and cytoplasm Loss of GABAergic neurons of basal ganglia 5-10/100,000 people, less common in Asian - Classic triad Early onset dementia, choreoathetosis, psychosis - Imaging Diffuse cerebral atrophy Atrophy of caudate nucleus, frontal horns enlarged, increased intercaudate distance, loss of convex surface of caudate head Decreased volume of basal ganglia, iron deposition T2 hyperintensity in caudate nucleus, putamen in juvenile HD |
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Correct Answer
Semi-Correct Answer |