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Case No. 412
2016-06-01~2016-06-30
출제자 : 이경식
Hit : 443
| Period | 2016-06-01~2016-06-30 |
|---|---|
| Diagnosis | PML (progressive multifocal leukoencephalopathy) |
| Clinical information | M/58 C.C> Rt. side weakness (10 days ago), dysarthria - underlying disease: AIDS * Initial (fig 1-6) and 1 month follow up MRIs (fig 7-9) |
| Discussion | PML (progressive multifocal leukoencephalopathy) Demyelinating disease which results from the JC virus infecting oligodendrocytes PML is strongly associated with immunosuppressed states, particularly AIDS, but also can occur in transplant patients and leukaemia Radiologic findings * multifocal, asymmetric periventricular and subcortical involvement is typical * MRI T1: low / T2: high T1 C+: typically there is no enhancement (if present may be associated with improved survival) DWI/ADC map: peripheral patchy diffusion restriction |
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