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Case No. 285
2012-11-01~2012-11-30
출제자 : 차지훈
Hit : 488
| Period | 2012-11-01~2012-11-30 |
|---|---|
| Diagnosis | Post-transplantion lymphoproliferative disorder |
| Clinical information | M/56, 8년 전에 liver transplantation 진단은? |
| Discussion | Post-transplantion lymphoproliferative disorder Incidence : 1% after renal transplantation to as high as 20% among small bowel recipients, and it is higher in children. Post-transplant PCNSL occurs in 0.3% of organ transplant recipients. About 15% of transplant recipients with PTLD have central nervous system (CNS) involvement. The median time from transplantation to diagnosis of PCNS-PTLD : 4.4 years Most patients had monomorphic, Epstein-Barr virus (EBV)-positive disease of B-cell origin. Median survival : 47 months. Radiologic findings Multiple (61-83%) Enhancement – heterogeneous (56%), ring (29%), homogenous (41%) Any location in brain, most commonly lobar, periventricular, basal ganglia References Primary central nervous system lymphoma after liver transplantation treated by radiosurgery combined with fractionated radiotherapy. J Clin Neurosci. 2009 Apr;16(4):583-5. Epub 2009 Feb 5. Post-transplantation primary central nervous system lymphoma: A case report and review of the literature. Surg Neurol Int. 2011;2:130. Epub 2011 Sep 27. Primary central nervous system post-transplantation lymphoproliferative disorder: an International Primary Central Nervous System Lymphoma Collaborative Group Report. Cancer. 2010 Feb 15;116(4):863-70. |
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