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Case No. 268
2012-04-02~2012-04-30
출제자 : 최승홍
Hit : 475
| Period | 2012-04-02~2012-04-30 |
|---|---|
| Diagnosis | Kimura disease |
| Clinical information | M/28 CC: Lt. eyelid swelling (6months) |
| Discussion | Kimura disease Kimura's disease (KD) was first described in 1948. It is one of the rare diseases that predominantly occurs in Asians, with hundreds of cases reported from China, Japan, Singapore, Indonesia, and Hong Kong under a variety of names. KD often presents with subcutaneous nodules and tumor-like masses affecting the head and neck region. Even though the most common location of the KD lesions are at the orbit, especially in the superior orbital space, KD is a rare diagnosis in ophthalmology. Other locations of KD lesions (in decreasing order) include the eyelid and orbit, the eyelid alone, the lacrimal gland alone, and the lacrimal gland and the eyelid. Histologically, KD lesions are characterized by dense fibrosis, capillary proliferation, and a chronic inflammatory cell infiltrate of lymphocytes, reactive lymphoid follicles, and aggregates of eosinophils. Typically, lymphocytes and lymphoid follicles with distinct germinal centers are present. The differential diagnosis of KD includes angiolymphoid hyperplasia with eosinophilia, angiosarcoma, pyogenic granuloma, Kaposi's sarcoma, epithelioid hemangioendothelioma, hamartoma, lymphoma, and an insect bite or sting. |
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