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종결 Case No. 161 0000-00-00~0000-00-00
출제자 : 관리자 Hit : 301
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Period 0000-00-00~0000-00-00
Diagnosis
Clinical information 69세 남자. Right femur neck fracture에 대한 evaluation도중 발견한 scalp mass.
Discussion Multiple myeloma involvement of T-spine & skull (bone marrow biopsy및 skull biopsy에 의하여 모두 confirmed됨)

Definition:
multifocal malignant proliferation of monoclonal plasma cells within bone marrow

Imaging findings:
Multifocal, diffuse, or heterogeneous T1hypointensity

Location: axial skeleton (red marrow)> long bones
Spine (87% vertebral compression Fx between T6 and L4), skull, ribs, pelvis

Size:
Variable
Well-circumscribed, punched-out lesions on plain-radiograph

Radiographic findings
Plain:
Diffuse osteropenia (85%), multiple osteolytic lesions (80%)
CT:
Multifocal osteolytic lesions/ vertebral compression Fx or destruction, extraosseous soft tissue component
MR:
Normal
Bone marrow involvement with focal, diffuse or variegated patterns

Nuclear Medicine
Bone scan:
typically negative, only 10% detected on bone scan
PET: metabolically active
Sensitivity: 84-92%, specificity: 83-100%

Reference: Diagnostic imaging Spine Amirsys press IV:1-66 to 68

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